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Tetracaine, also known as amethocaine, is an ester local anesthetic used to numb the eyes, nose, or throat. It may also be applied to the skin before starting an intravenous (injection) to decrease pain from the procedure. Typically it is applied as a liquid to the area. Onset of effects when used in the eyes is within 30 seconds and last for less than 15 minutes.
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Common side effects include a brief period of burning at the site of use. Allergic reactions may uncommonly occur. Long-term use is generally not recommended as it may slow healing of the eye. It is unclear if use during pregnancy is safe for the baby. Tetracaine is in the ester-type local anesthetic family of medications. It works by blocking the sending of nerve impulses.
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Tetracaine was patented in 1930 and came into medical use in 1941. It is on the World Health Organization’s List of Essential Medicines
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A systematic review investigated tetracaine for use in emergency departments, especially for starting intravenous lines in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first-attempt cannulations.
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Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
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In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
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Product Name: Tetracaine HCl
Alias: Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; Amethocaine hydrochloride
CAS NO.: 136-47-0
EINECS: 205-248-5
MF: C15H25ClN2O2
MW: 300.82
Assay: 99%
Grade: Pharmaceutical Grade
Product Categories: Amines;Heterocycles;Intermediates & Fine
Usage: Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.
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Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide. Buy Tetracaine powder tetracaine hcl
Tetracaine HCl Uses
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Buy Tetracaine powder tetracaine hcl
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.Buy Tetracaine powder tetracaine hcl
1. It is used in ophthalmology and otolaryngology.
2. It can be used in epidural block, subarachnoid block and nerve conduction block.
This product is a long-acting ester local anesthetic. Its characteristics are: strong penetration of mucous membrane, suitable for surface anesthesia, no vasoconstriction, mydriatic dilation, corneal damage and other adverse reactions after eye drop, commonly used in ophthalmology. Local anesthesia and toxicity are about 10 times greater than procaine. After injection, the anesthesia was slow (about 10 minutes), and the metabolism was slow after absorption. The local anesthesia lasted for 3 ij, h, – J. About. It is mainly used for the surface anesthesia of the mucous membrane of eyes, nose and throat, but seldom for conduction anesthesia and epidural anesthesia. Because of its toxicity, it is not generally used for infiltration anesthesia.Buy Tetracaine powder tetracaine hcl
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- ProName: tetracaine powder cas 136-47-0 in stoc…
- CasNo:136-47-0
- Molecular Formula:C15H25ClN2O2
- Appearance: white powder
- Application: chemical raw materials
- DeliveryTime:3-5 days
- PackAge:25kg/drum
- Port: shanghai
- ProductionCapacity:5000 Kilogram/Week
- Purity:99%
- Storage: in dry and cold
- Transportation: by express or air
- LimitNum:25 Kilogram
- Related Substances: chemicals
- Residue on Ignition: n/a
- Heavy Metal: n/a
- Valid Period:2 years
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